How Does Ozone Therapy Work?

• Ozone stimulates the body toward homeostasis by creating a mild, acute oxidative stress and activates the NRF2 pathway.  The NRF2 pathway is also activated during exercise and fasting.  The NRF2 pathway is the master regulator of antioxidant, detoxification and cell defense gene expression. It regulates over 600 genes involved in cellular protection and antioxidant defenses. It modulates numerous genes responsible for cognitive processes, inflammatory responses, rebuilding tissue, immune system response, and inhibiting cancer production and preventing its spread.

• Ozone up-regulates the body’s natural antioxidant production, thereby scavenging excess free radicals when needed, which is key in rejuvenation and overall health. Another very important pathway that is directly stimulated by Ozone therapy is called the NF kappa Beta (NFkB) Pathway. Nuclear factor kappa-β is a transcription factor that is the “master switch” for inflammation. Severe oxidative stress activates nuclear transcriptional factor kappa B (NFκB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines. However, moderate oxidative stress activates Nrf2 pathway. Nrf2 then induces the transcription of antioxidant response elements (ARE). These are very strong antioxidants.

• Ozone improves red blood cell and blood vessel flexibility and elasticity thereby improving blood circulation and improving oxygen delivery to harder-to-reach tissues of the body at the cellular level.  To the extent that ozone enhances blood flow, it relieves pain and inflammation.

• Ozone enhances oxygen metabolism and increases tissue oxygenation by infusing the mitochondria of the cell with oxygen, resulting in increased energy in the form NAD and ATP.  This energy is used to do exactly as the body needs and is often/usually felt by people as a noticeable ‘clear-headed energy.’

• Ozone therapy forms compounds called Ozonides. Ozonides are formed when Ozone comes in contact with lipids and amino acids in the blood. These Ozonides penetrate the cell membrane and oxidize NADH back to NAD helping to maintain an optimal NAD/NADH ratio.

• Ozone modulates the immune system (enhances it when needed like when infection is present and lowers it when needed like in autoimmunity).

• Ozonides also have a significant effect on cytokine production. Cytokines are messenger molecules that seem to have a significant effect especially on cells of the immune system. The importance of cytokines cannot be understated. Essentially all medical conditions are a result of an imbalance of cytokines.

• Ozone is a broad spectrum germicide (against viruses, bacteria, spirochetes, parasites, mycoplasma, fungus, etc.).